KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
7.88
Human Site:
Y523
Identified Species:
14.44
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
Y523
R
T
Q
K
E
L
A
Y
L
S
E
L
P
P
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
Y517
R
T
Q
K
E
L
A
Y
L
S
D
L
P
P
T
Dog
Lupus familis
XP_546130
745
81496
S521
Q
K
E
L
A
H
L
S
E
L
P
P
T
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
L513
P
P
R
P
Q
K
E
L
V
H
L
S
E
L
P
Rat
Rattus norvegicus
Q5RJQ4
350
39301
I132
L
R
C
Y
T
Q
N
I
D
T
L
E
R
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
S262
H
V
S
E
G
S
S
S
P
D
R
T
S
P
P
Chicken
Gallus gallus
NP_001004767
756
82614
H535
M
H
K
E
L
E
M
H
S
S
E
L
P
P
T
Frog
Xenopus laevis
NP_001091195
710
78684
Q485
T
N
F
L
K
L
S
Q
I
T
E
M
P
P
R
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
R161
K
D
K
G
L
L
R
R
C
Y
S
Q
N
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
S559
S
A
G
T
C
S
D
S
G
F
E
S
S
T
F
Honey Bee
Apis mellifera
XP_395386
868
98678
K601
S
T
S
K
D
I
G
K
I
Y
S
L
E
E
C
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
T389
G
S
F
T
E
L
I
T
S
Y
D
S
I
M
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
L285
L
Q
D
K
G
K
L
L
R
N
Y
T
Q
N
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
93.3
6.6
N.A.
0
0
N.A.
6.6
40
26.6
6.6
N.A.
6.6
20
13.3
N.A.
P-Site Similarity:
100
N.A.
100
20
N.A.
20
6.6
N.A.
20
60
60
20
N.A.
6.6
40
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
16
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
8
0
8
0
0
0
8
0
0
0
0
0
8
% C
% Asp:
0
8
8
0
8
0
8
0
8
8
16
0
0
0
8
% D
% Glu:
0
0
8
16
24
8
8
0
8
0
31
8
16
8
8
% E
% Phe:
0
0
16
0
0
0
0
0
0
8
0
0
0
0
8
% F
% Gly:
8
0
8
8
16
0
8
0
8
0
0
0
0
0
0
% G
% His:
8
8
0
0
0
8
0
8
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
8
16
0
0
0
8
8
8
% I
% Lys:
8
8
16
31
8
16
0
8
0
0
0
0
0
0
0
% K
% Leu:
16
0
0
16
16
39
16
16
16
8
16
31
0
8
8
% L
% Met:
8
0
0
0
0
0
8
0
0
0
0
8
0
8
0
% M
% Asn:
0
8
0
0
0
0
8
0
0
8
0
0
8
8
0
% N
% Pro:
8
8
0
8
0
0
0
0
8
0
8
8
31
47
16
% P
% Gln:
8
8
16
0
8
8
0
8
0
0
0
8
8
0
0
% Q
% Arg:
16
8
8
0
0
0
8
8
8
0
8
0
8
0
8
% R
% Ser:
16
8
16
0
0
16
16
24
16
24
16
24
16
0
0
% S
% Thr:
8
24
0
16
8
0
0
8
0
16
0
16
8
8
24
% T
% Val:
0
8
0
0
0
0
0
0
8
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
16
0
24
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _